Studies on cardiotonic agents. II. Synthesis of novel phthalazine and 1,2,3-benzotriazine derivatives.
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چکیده
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Maher A El-Hashash1, Dalal B Guirguis1*, Nayera AM Abd El-Wahed2 and Mohamed A Kadhim3 1Chemistry Department, Faculty of Science, Ain Shams University, Abassia 11566, Cairo, Egypt 2Department of Chemistry of Natural and Microbial Products, Division of Pharmaceutical Industries, National Research Center, El Behos street, Dokki, Egypt 3Chemistry Department, Faculty of Science, Anbar University, Iraq
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Preparation of 4-benzyl-2-substituted phthalazin-1-one derivatives 2-8 is reported. Condensation of 4-benzyl-1-chlorophthalazine (9) with a series of different nucleophiles gave 4-benzylphthalazin-1-ylamino derivatives (10-13 and 16) and 4-amino-2-[N'-(4-benzylphthalazin-1-yl)-hydrazino]-6-arylpyrimidine-5-carbonitriles (14a,b). Interaction of 9 with ambident anions was also studied. 5-Benzyl-6...
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ژورنال
عنوان ژورنال: Chemical and Pharmaceutical Bulletin
سال: 1990
ISSN: 0009-2363,1347-5223
DOI: 10.1248/cpb.38.2179